CENPE

Across TCGA cell cohorts, CENPE RNA expression is significantly associated with the go_rna of many other GO terms, with 4,341 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CENPE-associated GO terms across cancer lineages are Meiotic chromosome segregation, Positive regulation of cell cycle, and Spindle elongation. Each is linked with CENPE in more than 19 cancer types. Because this analysis shows association rather than direction, both CENPE-to-partner and partner-to-CENPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic chromosome segregation grouped by CENPE-low versus CENPE-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPE→partner) and Y-score (partner→CENPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Meiotic chromosome segregation →	+0.239	+1.411	<.001	<.001	3	20
UPPER_AERODIGESTIVE_TRACT	Positive regulation of cell cycle →	+0.089	+1.375	<.001	<.001	3	20
OESOPHAGUS	Spindle elongation →	+0.273	+1.483	<.001	<.001	3	20
BONE	Mitotic spindle midzone assembly →	+0.293	+1.329	.006	.002	3	20
BONE	Chromosome movement towards spindle pole →	+0.190	+1.139	<.001	<.001	3	20
KIDNEY	Attachment of mitotic spindle microtubules to kinetochore →	+0.168	+1.543	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,341 associations by consensus.

Meiotic chromosome segregation by CENPE expression — OESOPHAGUS

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