CENPE

Across TCGA cell cohorts, CENPE mutation is significantly associated with the RNA expression of many other genes, with 1,336 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CENPE-associated genes across cancer lineages are DESI1, CHIA, and S100A12. Each is linked with CENPE in more than 2 cancer types. Because this analysis shows association rather than direction, both CENPE-to-partner and partner-to-CENPE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DESI1 grouped by CENPE-low versus CENPE-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPE→partner) and Y-score (partner→CENPE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DESI1 →	+0.582	+3.321	<.001	.003	3	3
BONE	CHIA →	+0.032	+4.672	<.001	.001	3	2
BONE	S100A12 →	+0.035	+4.169	<.001	.008	3	2
BREAST	SLC16A5 →	+1.582	+3.220	.006	.005	3	2
BREAST	TMEM233 →	+0.046	+2.817	<.001	<.001	3	2
LARGE_INTESTINE	PLCD4 →	+0.434	+3.169	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,336 associations by consensus.

DESI1 by CENPE expression — LARGE_INTESTINE

Explore this box plot interactively →