CENPC

Across TCGA pan-cancer cohorts, CENPC mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CENPC’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CENPC mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CENPC is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where CENPC tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CENPC mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+0.350	<.001	11	view →
LSCC	All	II,III,IV	+0.200	<.001	8	view →
LUAD	Male	All	+0.156	<.001	7	view →
PDAC	Male	All	−0.325	.002	5	view →
HNSC	Male	All	+0.094	.047	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CENPC–CCRCC

Open the CCRCC breakdown →