CENPB

Across TCGA patient cohorts, CENPB mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CENPB-associated genes across cancer lineages are A-Raf_pS299, EGFR_pY1068, and IGFBP2. Each is linked with CENPB in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPB-to-partner and partner-to-CENPB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CENPB-low versus CENPB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPB→partner) and Y-score (partner→CENPB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.178	-3.169	.002	.019	3	2
UCEC	EGFR_pY1068 →	-0.315	-2.459	.009	.020	3	1
UCEC	IGFBP2 →	-0.732	-2.459	.019	.020	3	1
UCEC	N-Ras →	-0.153	-3.571	.007	.002	3	1
UCEC	p62 Lck ligand →	+0.733	+3.469	<.001	.002	3	1
UCEC	SF2 →	-0.168	-3.159	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

A-Raf_pS299 by CENPB expression — UCEC

Explore this box plot interactively →