CENPB

Across TCGA pan-cancer cohorts, CENPB RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CENPB’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CENPB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CENPB is over-expressed in tumor, although a few such as UCEC and PRAD show the opposite, repressed pattern.

HNSC, LIHC, and KIRP are the cancer types where CENPB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CENPB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.698	<.001	12	view →
LIHC	Female	II,III,IV	+1.281	<.001	9	view →
KIRP	All	II,III,IV	+0.615	.001	9	view →
COAD	Female	All	+0.774	<.001	8	view →
KIRC	Female	All	+0.478	<.001	8	view →
STAD	Male	II,III,IV	+1.103	<.001	7	view →
CHOL	All	All	+1.765	<.001	5	view →
LUSC	All	All	+0.408	<.001	5	view →
THCA	All	All	+0.243	<.001	5	view →
BRCA	All	III,IV	+0.434	.008	4	view →
UCEC	All	All	−0.323	.026	4	view →
ESCA	All	All	+0.813	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CENPB–HNSC

Open the HNSC breakdown →