CENPA

Across TCGA patient cohorts, CENPA protein abundance is significantly associated with the protein abundance of many other proteins, with 6,022 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CENPA-associated proteins across cancer lineages are TOP2A_T1343, CDK13_S420, and AHNAK_S5763. Each is linked with CENPA in more than 1 cancer types. Because this analysis shows association rather than direction, both CENPA-to-partner and partner-to-CENPA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CENPA versus TOP2A_T1343 in HNSC, with a Pearson correlation of 0.62.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CENPA→partner) and Y-score (partner→CENPA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TOP2A_T1343 →	+1.297	+0.823	<.001	.001	3	2
COAD	CDK13_S420 →	+2.213	+1.209	.001	<.001	3	1
COAD	AHNAK_S5763 →	-1.030	-1.115	.002	.004	3	1
COAD	ABRAXAS1 →	+0.896	+1.129	.004	<.001	3	1
COAD	SMIM15 →	+2.450	+1.209	<.001	<.001	3	1
COAD	SRRM2_S1577 →	+0.810	+1.209	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,022 associations by consensus.

CENPA vs TOP2A_T1343 — HNSC

Explore this scatter interactively →