CELSR1

Across TCGA pan-cancer cohorts, CELSR1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CELSR1 data layer compared with 22 for mass-spec protein and 12 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CELSR1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CELSR1 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where CELSR1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.454	0.822	<.001	63	view →
PDAC	OS	Median	All	0.270	0.502	<.001	62	view →
CCRCC	OS	Quartile	II,III,IV	0.506	1.000	<.001	42	view →
LUAD	DFS	Tertile	All	0.821	0.962	.002	25	view →
GBM	OS	Quartile	All	0.666	0.238	.010	11	view →
LSCC	DFS	Quartile	III,IV	1.000	0.748	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CELSR1–HNSC (DFS)

Open the HNSC breakdown →