CELSR1

Across TCGA pan-cancer cohorts, CELSR1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CELSR1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CELSR1 RNA is repressed in tumor relative to normal tissue. In most cancer types CELSR1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, COAD, and HNSC are the cancer types where CELSR1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CELSR1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−3.970	<.001	11	view →
COAD	Female	All	+2.332	<.001	11	view →
HNSC	Male	All	+1.566	<.001	11	view →
THCA	All	II,III,IV	−0.961	<.001	10	view →
STAD	All	II,III,IV	+1.659	<.001	9	view →
KIRC	Female	III,IV	+0.905	<.001	8	view →
LIHC	All	II,III,IV	+0.808	<.001	8	view →
BRCA	All	III,IV	+1.685	<.001	6	view →
LUSC	Male	All	+0.704	<.001	4	view →
CHOL	Male	All	+2.775	<.001	3	view →
READ	All	All	+1.307	.002	2	view →
UCEC	All	All	+1.037	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CELSR1–KICH

Open the KICH breakdown →