CELSR1

Across TCGA patient cohorts, CELSR1 mutation is significantly associated with the RNA expression of many other genes, with 7,496 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CELSR1-associated genes across cancer lineages are PBK, TMEM183A, and PSMA4. Each is linked with CELSR1 in more than 5 cancer types. Because this analysis shows association rather than direction, both CELSR1-to-partner and partner-to-CELSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by CELSR1-low versus CELSR1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR1→partner) and Y-score (partner→CELSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PBK →	+1.231	+3.338	<.001	.005	3	6
STAD	TMEM183A →	+0.284	+2.832	.007	.001	3	6
LUAD	PSMA4 →	+0.407	+2.709	<.001	.003	3	6
STAD	CENPM →	+0.739	+3.601	<.001	.001	3	6
STAD	ZIC5 →	+1.132	+1.864	<.001	.004	3	6
STAD	GTF2A2 →	+0.726	+2.803	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,496 associations by consensus.

PBK by CELSR1 expression — BRCA

Explore this box plot interactively →