CELSR1

Across TCGA patient cohorts, CELSR1 mutation is significantly associated with the total protein of many other genes, with 80 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CELSR1-associated genes across cancer lineages are ASNS, TFRC, and Caspase-7-cleavedD198. Each is linked with CELSR1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CELSR1-to-partner and partner-to-CELSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CELSR1-low versus CELSR1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR1→partner) and Y-score (partner→CELSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.479	+3.321	.039	.010	3	5
STAD	TFRC →	+0.481	+3.321	.026	.008	3	5
COAD	Caspase-7-cleavedD198 →	+1.032	+1.511	<.001	.018	3	5
STAD	Cyclin-E2 →	+0.125	+1.699	.007	.012	3	5
SKCM	MYH11 →	-0.734	-1.459	.008	.011	3	4
SKCM	STAT3_pY705 →	-0.226	-2.700	.009	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

ASNS by CELSR1 expression — LUAD

Explore this box plot interactively →