CELSR1

Across TCGA cell cohorts, CELSR1 mutation is significantly associated with the RNA expression of many other genes, with 1,208 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CELSR1-associated genes across cancer lineages are LRIT3, LARP1B, and GID4. Each is linked with CELSR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CELSR1-to-partner and partner-to-CELSR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRIT3 grouped by CELSR1-low versus CELSR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CELSR1→partner) and Y-score (partner→CELSR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRIT3 →	+0.153	+1.819	.001	.002	3	3
LARGE_INTESTINE	LARP1B →	+0.574	+2.546	.001	.001	3	3
LARGE_INTESTINE	GID4 →	+0.567	+2.377	<.001	<.001	3	3
LARGE_INTESTINE	ESCO1 →	+0.512	+1.977	<.001	<.001	3	3
BLOOD_Leukemia	SCD5 →	+1.334	+3.518	.001	<.001	3	3
LARGE_INTESTINE	IRAK1BP1 →	+0.533	+3.321	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,208 associations by consensus.

LRIT3 by CELSR1 expression — LARGE_INTESTINE

Explore this box plot interactively →