Across TCGA pan-cancer cohorts, CELF2-DT RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CELF2-DT’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CELF2-DT RNA is repressed in tumor relative to normal tissue. In most cancer types CELF2-DT is over-expressed in tumor, although a few such as KIRC and PRAD show the opposite, repressed pattern.
KIRC, PRAD, and BRCA are the cancer types where CELF2-DT tumor–normal differential expression is most reproducible.