CEL

Across TCGA pan-cancer cohorts, CEL Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CEL data layer compared with 21 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CEL Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CEL expression acts as an unfavorable survival marker.

HNSC, OV, and LGG are the cancer types where CEL Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.021	0.712	<.001	30	view →
OV	DFS	Median	All	0.160	0.541	.003	18	view →
LGG	OS	Median	All	0.147	0.811	<.001	12	view →
SCLC	OS	Median	IV	0.137	0.548	.004	12	view →
BRCA	DFS	Median	All	0.130	0.526	.021	8	view →
BLCA	OS	Median	IV	0.230	0.602	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CEL–HNSC (OS)

Open the HNSC breakdown →