CEL

Across TCGA cell cohorts, CEL mutation is significantly associated with the RNA expression of many other genes, with 328 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CEL-associated genes across cancer lineages are TRNAU1AP, SOX1, and MED31. Each is linked with CEL in more than 2 cancer types. Because this analysis shows association rather than direction, both CEL-to-partner and partner-to-CEL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRNAU1AP grouped by CEL-low versus CEL-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEL→partner) and Y-score (partner→CEL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRNAU1AP →	+0.483	+3.169	.009	.009	3	3
OVARY	SOX1 →	+0.781	+4.077	<.001	<.001	3	3
LARGE_INTESTINE	MED31 →	+0.640	+2.502	.002	.005	2	3
LARGE_INTESTINE	ZNF426 →	+0.881	+3.321	<.001	.003	3	2
LARGE_INTESTINE	TUT4 →	+0.916	+3.628	.003	<.001	3	2
LARGE_INTESTINE	TTPA →	+0.829	+3.628	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 328 associations by consensus.

TRNAU1AP by CEL expression — LARGE_INTESTINE

Explore this box plot interactively →