CEBPA-DT

Across TCGA pan-cancer cohorts, CEBPA-DT RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CEBPA-DT data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher CEBPA-DT RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CEBPA-DT expression acts as an unfavorable survival marker, although some lineages such as UVM and READ show a favorable association.

UVM, UCEC, and LIHC are the cancer types where CEBPA-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.804	0.379	<.001	125	view →
UCEC	DFS	Tertile	All	0.571	0.700	<.001	102	view →
LIHC	OS	Median	II,III,IV	0.621	0.805	.001	60	view →
READ	OS	Median	All	0.976	0.849	.002	55	view →
KIRP	OS	Median	II,III,IV	0.825	0.305	.001	43	view →
LUAD	OS	Tertile	All	0.858	0.683	.002	37	view →
DLBC	OS	Median	All	1.000	0.805	.006	36	view →
UCS	DFS	Median	II,III,IV	0.542	0.146	.004	30	view →
HNSC	DFS	Median	IV	0.713	0.571	.005	30	view →
KIRC	OS	Tertile	All	0.585	0.753	.008	15	view →
LUSC	OS	Median	All	0.811	0.711	.014	14	view →
STAD	DFS	Tertile	IV	0.254	0.805	.049	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CEBPA-DT–UVM (DFS)

Open the UVM breakdown →