CEACAM5

Across TCGA patient cohorts, CEACAM5 mutation is significantly associated with the RNA expression of many other genes, with 4,183 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEACAM5-associated genes across cancer lineages are CHAF1A, CEP78, and PAXIP1. Each is linked with CEACAM5 in more than 3 cancer types. Because this analysis shows association rather than direction, both CEACAM5-to-partner and partner-to-CEACAM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAF1A grouped by CEACAM5-low versus CEACAM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM5→partner) and Y-score (partner→CEACAM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAF1A →	+0.766	+2.506	<.001	<.001	3	4
UCEC	CEP78 →	+0.454	+1.695	<.001	.005	3	4
SKCM	PAXIP1 →	+0.339	+1.536	.003	.002	3	4
UCEC	PGAM5 →	+0.612	+2.169	<.001	<.001	3	3
LGG	BPNT2P →	+0.090	+4.620	<.001	.004	3	3
SKCM	FARSA →	+0.378	+2.907	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,183 associations by consensus.

CHAF1A by CEACAM5 expression — UCEC

Explore this box plot interactively →