CEACAM18

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, CEACAM18 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEACAM18-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Cyclin-B1, and ERK2. Each is linked with CEACAM18 in more than 2 cancer types. Because this analysis shows association rather than direction, both CEACAM18-to-partner and partner-to-CEACAM18 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM18→partner) and Y-score (partner→CEACAM18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECp38-MAPK_pT180_Y182 →-0.322-1.415.035.04333
UCECCyclin-B1 →+0.746+2.523<.001<.00133
UCECERK2 →+0.203+2.321.002.00532
UCECFoxM1 →+0.181+1.514.040.01532
UCECJNK_pT183_Y185 →-0.192-4.000<.001<.00132
UCECKu80 →+0.217+1.261.006.02932
Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

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