CEACAM1

Across TCGA patient cohorts, CEACAM1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CEACAM1-associated genes across cancer lineages are EGFR_pY1068, EGFR, and p62 Lck ligand. Each is linked with CEACAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CEACAM1-to-partner and partner-to-CEACAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CEACAM1-low versus CEACAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM1→partner) and Y-score (partner→CEACAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.317	-3.584	.003	.002	3	1
UCEC	EGFR →	-0.277	-3.459	<.001	.005	3	1
UCEC	p62 Lck ligand →	+0.468	+2.710	<.001	.003	3	1
UCEC	S6_pS240_S244 →	+0.408	+2.820	.021	.035	3	1
UCEC	SETD2 →	-0.200	-2.807	.036	.003	3	1
UCEC	STAT3_pY705 →	-0.381	-2.115	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by CEACAM1 expression — UCEC

Explore this box plot interactively →