CEACAM1

Across TCGA pan-cancer cohorts, CEACAM1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CEACAM1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CEACAM1 RNA is repressed in tumor relative to normal tissue. In most cancer types CEACAM1 is over-expressed in tumor, although a few such as HNSC and KIRP show the opposite, repressed pattern.

HNSC, KIRP, and KICH are the cancer types where CEACAM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CEACAM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−2.625	<.001	12	view →
KIRP	Male	III,IV	−2.252	<.001	11	view →
KICH	Male	II,III,IV	−2.496	<.001	10	view →
COAD	Female	All	−2.324	<.001	10	view →
KIRC	All	III,IV	−0.855	<.001	10	view →
LUAD	Female	II,III,IV	+2.041	<.001	8	view →
LIHC	All	III,IV	+0.733	<.001	7	view →
UCEC	All	All	+1.342	.002	6	view →
PAAD	All	All	+2.392	.001	4	view →
STAD	All	All	+1.344	.009	4	view →
LUSC	All	All	+0.669	<.001	4	view →
BRCA	Female	II,III,IV	−0.477	.008	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CEACAM1–HNSC

Open the HNSC breakdown →