CEACAM1

Across TCGA cell cohorts, CEACAM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,871 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible CEACAM1-associated GO terms across cancer lineages are Regulation of cytotoxic T cell degranulation, Negative regulation of cytotoxic T cell degranulation, and Negative regulation of T cell mediated cytotoxicity. Each is linked with CEACAM1 in more than 16 cancer types. Because this analysis shows association rather than direction, both CEACAM1-to-partner and partner-to-CEACAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytotoxic T cell degranulation grouped by CEACAM1-low versus CEACAM1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CEACAM1→partner) and Y-score (partner→CEACAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of cytotoxic T cell degranulation →	+2.172	+3.725	<.001	<.001	3	17
LIVER	Negative regulation of cytotoxic T cell degranulation →	+2.172	+3.725	<.001	<.001	3	17
LIVER	Negative regulation of T cell mediated cytotoxicity →	+1.976	+3.725	<.001	<.001	3	14
PANCREAS	Negative regulation of chemokine production →	+0.172	+2.603	<.001	<.001	3	11
BREAST	Positive regulation of chromatin binding →	+0.226	+1.665	<.001	.003	3	11
BLOOD_Lymphoma	Common myeloid progenitor cell proliferation →	-0.189	-1.249	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,871 associations by consensus.

Regulation of cytotoxic T cell degranulation by CEACAM1 expression — LIVER

Explore this box plot interactively →