CDYL

Across TCGA cell cohorts, CDYL mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CDYL-associated genes across cancer lineages are IFNG, RBMY1F, and C1QB. Each is linked with CDYL in more than 1 cancer types. Because this analysis shows association rather than direction, both CDYL-to-partner and partner-to-CDYL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNG grouped by CDYL-low versus CDYL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDYL→partner) and Y-score (partner→CDYL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	IFNG →	+0.016	+4.437	<.001	.004	3	1
SKIN	RBMY1F →	+0.052	+4.437	<.001	.004	3	1
SKIN	C1QB →	+0.049	+4.196	.007	.002	3	1
SKIN	TMEM150B →	+0.213	+3.793	<.001	.007	3	1
SKIN	PIGY →	+2.296	+3.920	.002	.005	3	1
LARGE_INTESTINE	TBR1 →	+0.030	+3.555	.009	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

IFNG by CDYL expression — SKIN

Explore this box plot interactively →