CDX4

Across TCGA patient cohorts, CDX4 protein abundance is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CDX4-associated genes across cancer lineages are TRIOBP, SIX4, and SH2D4A. Each is linked with CDX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDX4-to-partner and partner-to-CDX4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDX4 versus TRIOBP in HNSC, with a Pearson correlation of -0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDX4→partner) and Y-score (partner→CDX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRIOBP →	-0.684	-1.580	.004	.007	3	1
HNSC	SIX4 →	-1.345	-2.225	.008	<.001	3	1
HNSC	SH2D4A →	-1.266	-1.734	.002	.001	3	1
HNSC	CASP14 →	+5.353	+2.529	<.001	<.001	3	1
HNSC	LZTS2 →	-1.131	-1.734	.004	.001	3	1
HNSC	TRPV4 →	-1.487	-1.927	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

CDX4 vs TRIOBP — HNSC

Explore this scatter interactively →