CDX4

Across TCGA pan-cancer cohorts, CDX4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CDX4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CDX4 RNA is repressed in tumor relative to normal tissue. In most cancer types CDX4 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and PRAD are the cancer types where CDX4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDX4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.015	.001	6	view →
KICH	All	II,III,IV	−0.046	.007	5	view →
PRAD	All	All	−0.177	.003	2	view →
THCA	Female	All	+0.025	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CDX4–KIRC

Open the KIRC breakdown →