CDX4

Across TCGA patient cohorts, CDX4 mutation is significantly associated with the RNA expression of many other genes, with 2,820 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDX4-associated genes across cancer lineages are DHFRP5, EFL1, and CRTAC1. Each is linked with CDX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDX4-to-partner and partner-to-CDX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHFRP5 grouped by CDX4-low versus CDX4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDX4→partner) and Y-score (partner→CDX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DHFRP5 →	+0.035	+3.324	<.001	.003	3	3
UCEC	EFL1 →	+0.502	+2.010	<.001	<.001	3	3
UCEC	CRTAC1 →	-0.787	-2.321	.005	<.001	3	3
UCEC	GAK →	+0.277	+1.789	.004	.007	3	2
LUAD	EDC3 →	+0.322	+2.529	.002	.009	2	3
UCEC	HARBI1 →	+0.375	+2.290	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,820 associations by consensus.

DHFRP5 by CDX4 expression — LUAD

Explore this box plot interactively →