CDX4

Across TCGA patient cohorts, CDX4 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDX4-associated genes across cancer lineages are eEF2, PCNA, and TFRC. Each is linked with CDX4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDX4-to-partner and partner-to-CDX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CDX4-low versus CDX4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDX4→partner) and Y-score (partner→CDX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.256	+3.169	.043	.018	3	3
UCEC	PCNA →	+0.231	+2.087	.002	.005	3	2
UCEC	TFRC →	+0.566	+3.584	.002	.002	3	2
UCEC	VHL →	-0.965	-1.502	<.001	.027	3	2
UCEC	ASNS →	+0.379	+2.000	.002	.030	3	2
UCEC	Cyclin-B1 →	+0.725	+3.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

eEF2 by CDX4 expression — UCEC

Explore this box plot interactively →