CDX4

Across TCGA cell cohorts, CDX4 RNA expression is significantly associated with the mutation status of many other genes, with 84 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDX4-associated genes across cancer lineages are EXOC4, HCFC1, and FAM118A. Each is linked with CDX4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDX4-to-partner and partner-to-CDX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EXOC4 grouped by CDX4-low versus CDX4-high in CNS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDX4→partner) and Y-score (partner→CDX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	EXOC4 →	+4.035	+0.005	.006	<.001	3	2
CNS	HCFC1 →	+4.357	+0.006	.004	<.001	3	2
BONE	FAM118A →	+5.129	+0.012	<.001	<.001	3	1
BONE	MYO18B →	+4.129	+0.010	.001	<.001	3	1
BONE	ADAMTS13 →	+4.129	+0.010	.001	<.001	3	1
BONE	COL22A1 →	+4.129	+0.010	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 84 associations by consensus.

EXOC4 by CDX4 expression — CNS

Explore this box plot interactively →