CDX2

Across TCGA cell cohorts, CDX2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible CDX2-associated genes across cancer lineages are MRGPRG, SCN10A, and FCN2. Each is linked with CDX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDX2-to-partner and partner-to-CDX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRG grouped by CDX2-low versus CDX2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDX2→partner) and Y-score (partner→CDX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MRGPRG →	+0.032	+4.544	<.001	.003	3	1
LUNG_NSCLC_LUAD	SCN10A →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	FCN2 →	+0.039	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MAGEB10 →	+0.109	+4.930	<.001	.001	3	1
LARGE_INTESTINE	BTNL2 →	+0.081	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.039	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MRGPRG by CDX2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →