CDS2

Across TCGA pan-cancer cohorts, CDS2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CDS2 data layer compared with 20 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher CDS2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDS2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and GBM show a favorable association.

COAD, LUAD, and CCRCC are the cancer types where CDS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.835	1.000	.033	18	view →
LUAD	DFS	Median	II,III,IV	0.262	0.698	.027	15	view →
CCRCC	OS	Median	All	0.921	0.760	.012	14	view →
UCEC	DFS	Quartile	All	0.782	1.000	.014	10	view →
GBM	DFS	Tertile	All	0.876	0.666	.015	7	view →
HNSC	DFS	Median	All	0.698	1.000	.020	4	view →
LSCC	OS	Tertile	II,III,IV	0.669	0.897	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CDS2–COAD (DFS)

Open the COAD breakdown →