CDS2

Across TCGA pan-cancer cohorts, CDS2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CDS2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CDS2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDS2 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

HNSC, LUAD, and LIHC are the cancer types where CDS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.860	<.001	12	view →
LUAD	Female	II,III,IV	−1.017	<.001	8	view →
LIHC	Male	II,III,IV	+0.917	<.001	8	view →
THCA	Male	II,III,IV	−0.682	<.001	8	view →
UCEC	All	All	−0.977	<.001	6	view →
BLCA	Male	All	−0.661	.005	4	view →
KIRP	Female	II,III,IV	+0.541	.028	4	view →
BRCA	Female	All	−0.385	<.001	4	view →
LUSC	Male	All	−0.335	<.001	4	view →
CHOL	Female	All	+1.556	<.001	3	view →
KICH	All	All	−0.445	.002	2	view →
PRAD	All	All	−0.292	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CDS2–HNSC

Open the HNSC breakdown →