CDS2

Across TCGA patient cohorts, CDS2 mutation is significantly associated with the RNA expression of many other genes, with 497 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDS2-associated genes across cancer lineages are MIR4285, RNU2-45P, and MRPS15. Each is linked with CDS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDS2-to-partner and partner-to-CDS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4285 grouped by CDS2-low versus CDS2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDS2→partner) and Y-score (partner→CDS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4285 →	+0.698	+4.450	<.001	.002	3	2
LUAD	RNU2-45P →	+0.193	+4.631	<.001	.008	3	2
UCEC	MRPS15 →	+0.438	+3.627	.001	.001	3	2
UCEC	SNRPA1 →	+0.426	+3.700	.001	.001	3	2
UCEC	NABP2 →	+0.345	+3.191	.008	<.001	3	2
UCEC	CHMP7 →	+0.421	+2.815	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 497 associations by consensus.

MIR4285 by CDS2 expression — CESC

Explore this box plot interactively →