CDS1

Across TCGA patient cohorts, CDS1 mutation is significantly associated with the RNA expression of many other genes, with 2,036 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDS1-associated genes across cancer lineages are ZNF57, PIGG, and MRPL43. Each is linked with CDS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDS1-to-partner and partner-to-CDS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF57 grouped by CDS1-low versus CDS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDS1→partner) and Y-score (partner→CDS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF57 →	+0.454	+2.425	<.001	.002	3	2
UCEC	PIGG →	+0.406	+3.617	.002	.001	3	2
UCEC	MRPL43 →	+0.333	+3.162	.007	<.001	3	2
UCEC	PITHD1 →	+0.403	+2.524	.001	.009	3	2
READ	LINC02629 →	+0.077	+5.653	<.001	.003	3	2
READ	LINC02497 →	+0.094	+5.653	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,036 associations by consensus.

ZNF57 by CDS1 expression — UCEC

Explore this box plot interactively →