Across TCGA pan-cancer cohorts, CDRT8 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CDRT8’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CDRT8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDRT8 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
KIRC and BRCA are the cancer types where CDRT8 tumor–normal differential expression is most reproducible.