Across TCGA patient cohorts, CDR1 mutation is significantly associated with the RNA expression of many other genes, with 4,137 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDR1-associated genes across cancer lineages are RNU4-58P, MRPS30, and INCENP. Each is linked with CDR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDR1-to-partner and partner-to-CDR1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDR1→partner) and Y-score (partner→CDR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU4-58P →	+0.236	+3.434	.006	.006	3	3
UCEC	MRPS30 →	+0.356	+3.849	.003	<.001	3	3
UCEC	INCENP →	+0.617	+2.938	.001	<.001	3	3
UCEC	PRKCZ →	+0.511	+2.491	<.001	<.001	3	3
UCEC	POLR2E →	+0.612	+3.584	<.001	<.001	3	3
BRCA	RNA5SP414 →	+0.216	+8.471	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,137 associations by consensus.

Exploration

CDR1 survival (RNA) · tumor vs normal (RNA) · all CDR1 data types