Across TCGA pan-cancer cohorts, CDO1 mass-spec protein differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CDO1’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LSCC), where CDO1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CDO1 is over-expressed in tumor, although a few such as LSCC show the opposite, repressed pattern.
LSCC are the cancer types where CDO1 tumor–normal differential expression is most reproducible.