CDO1

Across TCGA patient cohorts, CDO1 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDO1-associated genes across cancer lineages are C-Raf, Notch1, and STAT3_pY705. Each is linked with CDO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDO1-to-partner and partner-to-CDO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by CDO1-low versus CDO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDO1→partner) and Y-score (partner→CDO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.214	+2.906	<.001	.001	3	2
UCEC	Notch1 →	+0.295	+2.662	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.362	-1.896	<.001	.015	3	2
UCEC	Caspase-7-cleavedD198 →	+0.666	+3.604	.002	.001	3	2
UCEC	Chk2_pT68 →	-0.180	-2.690	.010	.006	3	2
COAD	Myosin-IIa →	-0.215	-3.000	.041	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

C-Raf by CDO1 expression — UCEC

Explore this box plot interactively →