CDKN2A

Across TCGA patient cohorts, CDKN2A protein abundance is significantly associated with the RNA expression of many other genes, with 4,323 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CDKN2A-associated genes across cancer lineages are CDKN2B, CDKN2B-AS1, and CDKN2A-DT. Each is linked with CDKN2A in more than 6 cancer types. Because this analysis shows association rather than direction, both CDKN2A-to-partner and partner-to-CDKN2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDKN2A versus CDKN2B in GBM, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN2A→partner) and Y-score (partner→CDKN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDKN2B →	+2.489	+1.011	<.001	<.001	3	7
GBM	CDKN2B-AS1 →	+1.715	+0.965	<.001	<.001	3	7
GBM	CDKN2A-DT →	+1.163	+1.032	<.001	<.001	3	6
GBM	MTAP →	+1.258	+0.920	<.001	<.001	3	5
LUAD	DMRTA1 →	+0.947	+0.837	.002	<.001	3	4
OV	KDM4C →	+0.872	+0.987	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,323 associations by consensus.

CDKN2A vs CDKN2B — GBM

Explore this scatter interactively →