CDKN2A

Across TCGA pan-cancer cohorts, CDKN2A RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CDKN2A data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher CDKN2A RNA is associated with better overall survival. In most high-consensus cancer types, elevated CDKN2A expression acts as an unfavorable survival marker, although some lineages such as MESO and HNSC show a favorable association.

MESO, ACC, and COAD are the cancer types where CDKN2A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.696	0.383	<.001	126	view →
ACC	DFS	Median	All	0.251	0.625	<.001	119	view →
COAD	OS	Quartile	II,III,IV	0.744	0.962	<.001	116	view →
UCEC	DFS	Median	All	0.548	0.736	<.001	100	view →
UVM	OS	Tertile	II,III,IV	0.705	1.000	.007	61	view →
LIHC	DFS	Median	All	0.455	0.626	<.001	50	view →
KICH	OS	Tertile	All	0.814	1.000	.003	35	view →
PRAD	DFS	Median	All	0.691	0.875	<.001	30	view →
THCA	DFS	Tertile	All	0.735	0.902	.011	28	view →
HNSC	DFS	Quartile	All	0.724	0.540	<.001	26	view →
UCS	DFS	Tertile	IV	0.275	0.861	.024	24	view →
LUAD	OS	Tertile	II,III,IV	0.589	0.748	.017	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CDKN2A–MESO (OS)

Open the MESO breakdown →