CDKN2A

Across TCGA patient cohorts, CDKN2A mutation is significantly associated with the total protein of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKN2A-associated genes across cancer lineages are ASNS, eEF2, and PKC-a_pS657. Each is linked with CDKN2A in more than 3 cancer types. Because this analysis shows association rather than direction, both CDKN2A-to-partner and partner-to-CDKN2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by CDKN2A-low versus CDKN2A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN2A→partner) and Y-score (partner→CDKN2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.678	+3.459	<.001	.005	3	4
UCEC	eEF2 →	+0.370	+2.700	.002	.005	3	3
BLCA	PKC-a_pS657 →	-0.254	-1.807	.037	.026	3	3
STAD	c-Kit →	-0.296	-2.321	.038	.034	3	3
HNSC	Smad3 →	+0.131	+1.522	.010	.012	3	3
UCEC	FASN →	+0.418	+2.459	.002	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

ASNS by CDKN2A expression — STAD

Explore this box plot interactively →