CDKN1C

Across TCGA pan-cancer cohorts, CDKN1C mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CDKN1C data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CDKN1C mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CDKN1C expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and UCEC are the cancer types where CDKN1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.750	0.191	.001	21	view →
CCRCC	DFS	Median	III,IV	0.985	0.067	.008	19	view →
UCEC	DFS	Tertile	III,IV	0.350	1.000	.013	16	view →
GBM	OS	Median	All	0.206	0.555	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CDKN1C–PDAC (OS)

Open the PDAC breakdown →