CDKN1C

Across TCGA patient cohorts, CDKN1C mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKN1C-associated genes across cancer lineages are JNK2, Ku80, and MEK1. Each is linked with CDKN1C in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN1C-to-partner and partner-to-CDKN1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by CDKN1C-low versus CDKN1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN1C→partner) and Y-score (partner→CDKN1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.344	+3.009	<.001	.019	3	1
UCEC	Ku80 →	+0.313	+2.179	.008	.034	3	1
UCEC	MEK1 →	+0.610	+3.459	<.001	.005	3	1
UCEC	PKC-a →	+0.428	+2.321	.035	.035	3	1
UCEC	Tuberin →	+0.406	+2.321	.002	.035	3	1
UCEC	VEGFR2 →	+0.503	+2.817	<.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK2 by CDKN1C expression — UCEC

Explore this box plot interactively →