CDKN1B

Across TCGA pan-cancer cohorts, CDKN1B mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CDKN1B data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher CDKN1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CDKN1B expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where CDKN1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.469	0.287	.014	21	view →
LUAD	OS	Tertile	II,III,IV	0.894	0.293	.003	21	view →
CCRCC	DFS	Tertile	II,III,IV	0.772	0.453	.026	5	view →
HNSC	DFS	Quartile	II,III,IV	0.886	0.988	.038	4	view →
GBM	OS	Median	All	0.612	0.444	.027	2	view →
LSCC	DFS	Median	All	0.860	0.720	.013	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CDKN1B–PDAC (DFS)

Open the PDAC breakdown →