CDKN1B

Across TCGA patient cohorts, CDKN1B mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKN1B-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and ERK2. Each is linked with CDKN1B in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN1B-to-partner and partner-to-CDKN1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CDKN1B-low versus CDKN1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN1B→partner) and Y-score (partner→CDKN1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.422	+3.469	.002	.002	3	2
UCEC	EGFR_pY1068 →	-0.242	-3.169	.027	.019	3	1
UCEC	ERK2 →	+0.218	+3.169	.009	.018	3	1
UCEC	FoxM1 →	+0.307	+2.469	.006	.010	3	1
UCEC	GATA6 →	-0.148	-2.577	.039	.011	3	1
UCEC	INPP4B →	-0.304	-2.321	.031	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

p62 Lck ligand by CDKN1B expression — UCEC

Explore this box plot interactively →