CDKN1A

Across TCGA pan-cancer cohorts, CDKN1A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CDKN1A data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CDKN1A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDKN1A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

CCRCC, HNSC, and LUAD are the cancer types where CDKN1A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.810	1.000	.010	3	view →
HNSC	DFS	Tertile	III,IV	1.000	0.894	.041	2	view →
LUAD	OS	Quartile	All	1.000	0.731	.040	1	view →
LSCC	DFS	Median	III,IV	0.805	0.435	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CDKN1A–CCRCC (DFS)

Open the CCRCC breakdown →