CDKN1A

Across TCGA patient cohorts, CDKN1A mutation is significantly associated with the RNA expression of many other genes, with 338 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKN1A-associated genes across cancer lineages are HMGB1P22, RNU6-1118P, and RN7SL776P. Each is linked with CDKN1A in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN1A-to-partner and partner-to-CDKN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P22 grouped by CDKN1A-low versus CDKN1A-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN1A→partner) and Y-score (partner→CDKN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	HMGB1P22 →	+0.287	+4.539	<.001	.008	3	2
BLCA	RNU6-1118P →	+0.191	+4.040	<.001	.007	3	2
BLCA	RN7SL776P →	+0.045	+5.051	<.001	.001	3	2
SKCM	RN7SL111P →	+0.171	+4.310	.004	.003	3	2
UCEC	RNU6-894P →	+0.261	+3.879	<.001	.009	3	2
UCEC	GUSBP16 →	+0.080	+2.600	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 338 associations by consensus.

HMGB1P22 by CDKN1A expression — CESC

Explore this box plot interactively →