CDKN1A

Across TCGA patient cohorts, CDKN1A mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDKN1A-associated genes across cancer lineages are PEA-15, Ku80, and Rictor_pT1135. Each is linked with CDKN1A in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN1A-to-partner and partner-to-CDKN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15 grouped by CDKN1A-low versus CDKN1A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN1A→partner) and Y-score (partner→CDKN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PEA-15 →	-0.236	-2.982	.034	.036	3	1
UCEC	Ku80 →	+0.404	+3.183	.001	.010	3	1
UCEC	Rictor_pT1135 →	-0.172	-3.169	.002	.020	3	1
UCEC	Tuberin →	+0.482	+3.009	.001	.019	3	1
UCEC	VHL →	-1.457	-3.169	<.001	.019	3	1
UCEC	ASNS →	+0.642	+3.000	.001	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

PEA-15 by CDKN1A expression — BLCA

Explore this box plot interactively →