CDKN1A

Across TCGA cell cohorts, CDKN1A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,640 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible CDKN1A-associated GO terms across cancer lineages are Cellular response to cell-matrix adhesion, Reduction of food intake in response to dietary excess, and Mitotic G1/S transition checkpoint signaling. Each is linked with CDKN1A in more than 16 cancer types. Because this analysis shows association rather than direction, both CDKN1A-to-partner and partner-to-CDKN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to cell-matrix adhesion grouped by CDKN1A-low versus CDKN1A-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN1A→partner) and Y-score (partner→CDKN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Cellular response to cell-matrix adhesion →	+0.490	+2.003	.005	.003	3	17
BONE	Reduction of food intake in response to dietary excess →	+1.103	+2.615	<.001	<.001	3	15
STOMACH	Mitotic G1/S transition checkpoint signaling →	+0.106	+1.796	<.001	.001	3	13
OVARY	Stress-induced premature senescence →	+0.198	+2.833	<.001	<.001	3	13
LARGE_INTESTINE	Regulation of cardiolipin metabolic process →	-0.146	-1.887	<.001	<.001	3	12
OVARY	Tissue regeneration →	+0.119	+2.647	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,640 associations by consensus.

Cellular response to cell-matrix adhesion by CDKN1A expression — BLOOD_Myeloma

Explore this box plot interactively →