CDKN1A

Across TCGA cell cohorts, CDKN1A mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible CDKN1A-associated genes across cancer lineages are CNGA3, LCE2C, and GAGE2E. Each is linked with CDKN1A in more than 1 cancer types. Because this analysis shows association rather than direction, both CDKN1A-to-partner and partner-to-CDKN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNGA3 grouped by CDKN1A-low versus CDKN1A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN1A→partner) and Y-score (partner→CDKN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CNGA3 →	+0.016	+3.700	<.001	.002	3	1
URINARY_TRACT	LCE2C →	+0.070	+3.459	<.001	.002	3	1
URINARY_TRACT	GAGE2E →	+2.024	+3.845	.007	.001	3	1
LARGE_INTESTINE	OR4F4 →	+0.025	+4.273	<.001	.006	3	1
LARGE_INTESTINE	OR2V1 →	+0.042	+4.095	.004	.009	3	1
URINARY_TRACT	AGXT →	+0.202	+3.714	.009	.002	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CNGA3 by CDKN1A expression — URINARY_TRACT

Explore this box plot interactively →