CDKN1A

Across TCGA cell cohorts, CDKN1A mutation is significantly associated with the mutation status of many other genes, with 928 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDKN1A-associated genes across cancer lineages are NTAN1, CDIP1, and MMP9. Each is linked with CDKN1A in more than 2 cancer types. Because this analysis shows association rather than direction, both CDKN1A-to-partner and partner-to-CDKN1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NTAN1 grouped by CDKN1A-low versus CDKN1A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKN1A→partner) and Y-score (partner→CDKN1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NTAN1 →	+3.087	+4.392	.005	.005	1	3
LARGE_INTESTINE	CDIP1 →	+5.087	+4.523	.006	.006	1	2
BLOOD_Lymphoma	MMP9 →	+4.014	+4.969	.008	.008	1	2
BLOOD_Lymphoma	ARHGEF7 →	+4.014	+4.969	.008	.008	1	2
BLOOD_Lymphoma	PON3 →	+6.014	+6.014	.001	.001	1	2
URINARY_TRACT	KCNB2 →	+4.146	+3.137	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 928 associations by consensus.

NTAN1 by CDKN1A expression — LARGE_INTESTINE

Explore this box plot interactively →