CDKL5

Across TCGA patient cohorts, CDKL5 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,531 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CDKL5-associated proteins across cancer lineages are CDKL5_S306, LRP1, and CDH13. Each is linked with CDKL5 in more than 7 cancer types. Because this analysis shows association rather than direction, both CDKL5-to-partner and partner-to-CDKL5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDKL5 versus CDKL5_S306 in UCEC, with a Pearson correlation of 0.76.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL5→partner) and Y-score (partner→CDKL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDKL5_S306 →	+0.842	+0.933	<.001	<.001	3	8
OV	LRP1 →	+0.619	+0.635	<.001	.001	3	7
GBM	CDH13 →	+0.648	+0.604	<.001	<.001	3	7
OV	CDKL5_S407 →	+1.174	+1.009	<.001	<.001	3	7
BRCA	TLN2 →	+0.443	+0.567	<.001	<.001	3	6
UCEC	PDLIM7 →	+0.608	+0.400	.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,531 associations by consensus.

CDKL5 vs CDKL5_S306 — UCEC

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