Across TCGA patient cohorts, CDKL4 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,119 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CDKL4-associated proteins across cancer lineages are SAE1, SERPINB1, and HNRNPUL1. Each is linked with CDKL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDKL4-to-partner and partner-to-CDKL4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL4→partner) and Y-score (partner→CDKL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SAE1 →	+0.382	+0.451	<.001	<.001	3	3
HNSC	SERPINB1 →	-0.595	-0.687	<.001	<.001	3	3
GBM	HNRNPUL1 →	+0.336	+0.442	<.001	<.001	3	3
GBM	IRF2BP1_S384 →	+0.424	+0.575	<.001	.003	3	3
HNSC	UPP1 →	-0.897	-0.522	<.001	.001	3	3
PDAC	RAP1GAP_S484 →	+1.057	+0.222	.007	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,119 associations by consensus.

Exploration

CDKL4 survival (RNA) · tumor vs normal (RNA) · all CDKL4 data types